Clotrimazole as an amplifier of hemin-induced damage to human erythrocytes. Antioxidant-independent protective effects of flavonoids

Autor:	Fazoil I. Ataullakhanov, Volkova Ri, V. M. Nesterenko, Irina M. Shcherbachenko, I. L. Lisovskaya
Rok vydání:	2011
Předmět:	Antioxidant Clotrimazole medicine.medical_treatment Biophysics Antifungal drug Cell Biology medicine.disease Biochemistry Hemolysis chemistry.chemical_compound chemistry medicine Taxifolin heterocyclic compounds Trolox Quercetin medicine.drug Hemin
Zdroj:	Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 5:37-44
ISSN:	1990-7494 1990-7478
DOI:	10.1134/s1990747810061029
Popis:	This study is focused on the effect of the antifungal drug clotrimazole (CLT), also possessing anti-malarial and anticancer activities, on hemin-induced hemolysis and changes in ion permeability and filter-ability of human erythrocytes. In the presence of 10 μM clotrimazole, the hemolytic response of erythrocytes to exogenous hemin at concentrations as low as 2–8 μM was considerably potentiated and their filterability, as measured by passing them through a 5-μm nuclepore filter, dropped sharply. Flavonoids quercetin (Q) and taxifolin (DHQ), unlike the standard antioxidant Trolox, abolished the effects of clotrimazole, suggesting that protection of hemin-treated erythrocytes by flavonoids is not related to their antioxidant properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0dc7814c0b9d6bac5bdfbb0253159191 https://doi.org/10.1134/s1990747810061029 Zobrazit plný text záznamu Full text from SpringerLink