DIFFERENTIAL SUSCEPTIBILITY TO OXIDANT EXPOSURE IN INBRED STRAINS OF MICE: NITROGEN DIOXIDE VERSUS OZONE

Autor:	George J. Jakab, Steven R. Kleeberger, Liu Yi Zhang
Rok vydání:	1997
Předmět:	Ozone Health Toxicology and Mutagenesis Inflammation respiratory system Lung injury Toxicology Microbiology Pathogenesis chemistry.chemical_compound chemistry Inbred strain Air pollutants Immunology medicine Nitrogen dioxide medicine.symptom Cytotoxicity
Zdroj:	Inhalation Toxicology. 9:601-621
ISSN:	1091-7691 0895-8378
Popis:	The contribution of genetic background to the pathogenesis of airway responses to environmental agents including air pollutants is becoming increasingly clear. Characterization of genetic mechanisms of response to these agents may assist in the identification of susceptible individuals and populations. The primary objective of this investigation was to utilize inbred strains of mice to determine (1) whether there was significant genetic contribution in susceptibility to lung injury and inflammation induced by single and repeated acute exposures to nitrogen dioxide (NO2) and (2) whether similar genetic factors control sus- ceptibility to lung injury induced by NO2 and another oxidant, ozone (O3). Nine strains of inbred mice (male, 5-6 wk) were studied: 129/ J, A/ J, AKR/ J, BALB/ cJ, C3H/ HeJ, C57BL/6J, DBA/2J, SJL/J, and SWR/J. Each was exposed for 3 h to filtered air (controls) or 15 ppm NO2, and cellular inflammation, epithelial injury, and cytotoxicity were measured 2, 6, and 24 h thereafter. NO2 expos...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0db553fa03f5a70a54c479c4e69d710b https://doi.org/10.1080/089583797198006 Zobrazit plný text záznamu