Development of an Efficient Scale-Up Synthesis Method for a β3-Adrenergic Receptor Agonist, Ritobegron Ethyl Hydrochloride
| Autor: | Kyoko Nakagawa-Goto, Hidetoshi Isawa, Tetsuji Ozawa, Masahiro Kobayashi, Takehiro Ishikawa, Masayuki Nishimura, Norihiko Kikuchi, Ritsu Suzuki, Junichi Sonehara, Yohei Saito, Takayuki Ainai, Kiyoshi Kasai, Kobayashi Makoto |
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| Rok vydání: | 2020 |
| Předmět: |
Agonist
β3 adrenergic receptor 010405 organic chemistry medicine.drug_class Chemistry Hydrochloride Organic Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Coupling (electronics) chemistry.chemical_compound Ritobegron medicine sense organs Physical and Theoretical Chemistry Receptor |
| Zdroj: | Organic Process Research & Development. 24:1675-1682 |
| ISSN: | 1520-586X 1083-6160 |
| DOI: | 10.1021/acs.oprd.0c00278 |
| Popis: | An efficient route for the multikilogram synthesis of a selective β3-adrenergic receptor agonist, ritobegron ethyl hydrochloride (1), was developed by changing the coupling method of 4-hydroxynorep... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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