Ion-Pair Chromatographic Separation of Nomifensine Maleate Enantiomers

Autor:	Takeo Kuriki, Takehiko Fukunaga, Nobuo Suzuki, Tsuyoshi Tsujiyama, Misao Tsuchiya, Yozo Hamachi
Rok vydání:	1989
Předmět:	chemistry.chemical_classification Chloroform Chromatography Ion chromatography Analytical Chemistry Standard curve chemistry.chemical_compound Nomifensine chemistry medicine Methanol Enantiomer Counterion Enantiomeric excess medicine.drug
Zdroj:	Analytical Sciences. 5:285-288
ISSN:	1348-2246 0910-6340
DOI:	10.2116/analsci.5.285
Popis:	An ion-pair chromatographic method for separation of enantiomers of nomifensine maleate was established. Chiral separation was achieved by chromatography for N trifluoroacetylated nomifensine maleate enantiomers on Supherisorb Silica 5μm, a normal phase column, using a mixture of chloroform, methanol and water (100:3:0.15) containing a chiral counter ion, (+)-camphor-10-sulfonic acid (2×10-3mol l-1) as the mobile phase. The standard curve obtained was straight line passing through the orgin; this extended from 25ng to 25μg of the injected material. The results suggested that the proposed method is simple and rapid enough to be applied for the purity test of nomifensine maleate enantiomers.
Databáze:	OpenAIRE
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