POS0571 THE ROLE OF PROINFLAMMATORY CYTOKINES (IL-6 AND IL-17) IN PREDICTING 6-YEAR RESULTS OF EARLY RA THERAPY
| Autor: | V. Rybakova, A. Avdeeva, E. Nasonov |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Annals of the Rheumatic Diseases. 81:551-552 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2022-eular.4615 |
| Popis: | ObjectivesTo evaluate the dynamics of indicators of the cytokine profile and determine their role in predicting long-term results of early rheumatoid arthritis (RA) therapy.MethodsThe research included 93 patients with early RA (16 men and 77 women), average age Me;IQR (58 [49; 66] years), the duration of the disease 7 [4-11,5] months, DAS28-ESR high 59.7% and moderate activity 38.8%. All patients were prescribed a subcutaneous form of methotrexate (MT) at an initial dose of 10 mg / week with a rapid escalation of the dose to 20-30 mg / week. If the effectiveness of the therapy was insufficient, biologics were prescribed. The concentration of 27 cytokines in the blood serum: IL-1b, IL-1Pa, IL-2,-4,-5,-6,-7,-8,-9,-10,-12,-13,-15,-17, Eotaxin, FGF-basic, IFN-γ, IP-10, MCP-1, MIP-1α, MIP-1β, RANTES, TNF-α, VEGF (pg/ml) were determined with the help of the multiplex xMAR technology on the Bio-Plex array system analyzer (BIORAD, USA).ResultsBefore the start of the therapy, the DAS 28-ESR was 5.31 [4.79; 6.14], SDAI – 28.27 [18.79; 40.73], after 6 years, the DAS28-ESR was 4.0 [3.4; 4.59], SDAI - 15.06 [9.32; 21]; remission of the disease: DAS 28-ESR was detected in 7.8%, SDAI-5.3%; the low activity: DAS28-ESR in 21%, SDAI in 30.1 %, moderate activity: 60% according to DAS28-ESR, 56% according to SDAI, high activity: 11.2% according to DAS28-ESR, 8.6% according to SDAI.Prior to the start of therapy, the group of patients with RA had a higher level of pro-inflammatory cytokines (IL -6, IL -12, IL -15, IL -17), anti-inflammatory (IL -5, IL -13), chemokines (IP- 10, MIP-1ß, IL-8) and growth factors (IL -7, PDGF-BB, VEGF) compared with healthy donors (pConclusionThe evaluation of the level of proinflammatory cytokines (IL -6, IL -17), chemokines IP-10, immunoregulatory cytokine IL -9 after 12 weeks and 24weeks of the initiation of therapy allows to identify a group with the worst long-term prognosis.Disclosure of InterestsNone declared. |
| Databáze: | OpenAIRE |
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