ORIGINAL ARTICLE: Are Anti-Beta2-Glycoprotein-I Antibodies Markers for Recurrent Pregnancy Loss in Lupus Anticoagulant/Anticardiolipin Seronegative Women?
| Autor: | Jaume Alijotas-Reig, Raquel Ferrer-Oliveras, Elisa Llurba-Olive, Manel Casellas-Caro, Eduard Hermosilla, Miquel Vilardell-Tarrés, Lluis Cabero-Roura |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Lupus anticoagulant Pregnancy biology Obstetrics business.industry Immunology Autoantibody Obstetrics and Gynecology medicine.disease Thrombosis Reproductive Medicine Antiphospholipid syndrome Recurrent miscarriage biology.protein medicine Immunology and Allergy Antibody business Cohort study |
| Zdroj: | American Journal of Reproductive Immunology. 60:229-237 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.2008.00618.x |
| Popis: | PROBLEM Anti-beta(2)-Glicoprotein-1 antibodies (anti-beta(2)GPI-ab) have been related to recurrent miscarriage (RM) with conflicting results. The aim was to evaluate the role of anti-beta(2)-GPI-ab as unique biological marker in RM related to antiphospholipid (aPL). METHOD OF STUDY A cohort study that included 59 cases, divided in two groups, was designed: group 1 comprised 43 pregnant women with 'obstetric' antiphospholipid syndrome (APS) and group 2 included 16 cases with similar complaints but only having repeatedly anti-beta(2)-GPI-ab. Previous thrombosis and/or inherited thrombophilia were excluded. Lupus anticoagulant, anticardiolipin antibodies (aCA), anti-beta(2)-GPI-ab, and other autoantibodies were analyzed. Miscarriages, premature births, pre-eclampsia, live births, placental and systemic thromboses were studied. RESULTS No differences in previous obstetric complications were detected (P = 1.00-0.164). After the treatment, differences in number of obstetric complications were not seen (P = 1.00). Live births were similar in two groups (88.4% and 93.7%; P = 1.00). Placental thrombosis was equal in both groups, 93.3% versus 80% (P = 1.00). CONCLUSION These results suggest that anti-beta(2)-GPI-ab may be considered a biological marker for obstetric APS. |
| Databáze: | OpenAIRE |
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