Development of Tumors in the Rat Ovary After Transplantation into the Spleen
| Autor: | Gerson S. Biskind, Morton S. Biskind |
|---|---|
| Rok vydání: | 1944 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Portal circulation Spleen Ovary Estrone Biology General Biochemistry Genetics and Molecular Biology Transplantation chemistry.chemical_compound Functional integrity medicine.anatomical_structure Endocrinology chemistry Estrogen Internal medicine medicine Mesentery |
| Zdroj: | Experimental Biology and Medicine. 55:176-179 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-55-14507 |
| Popis: | It has been shown by Golden and Sevring-haus1 that rats in which the ovaries have been transplanted to the mesentery remain anestrous, owing to inactivation in the liver (previously reported by Zondek2) of the estrogen thus secreted into the portal circulation. Thereafter for approximately 11 monthsThis phenomenon was more extensively studied by G. R. Biskind3, 4, 5, 6 using pellets of crystalline steroids implanted in another organ in the portal circulation, the spleen. Castrate rats on a complete diet with pellets of estrone or estradiol thus implanted likewise remained anestrous. During the course of an investigation on the effect of nutritional deficiency on the estrogen-inactivating function of the liver,7-9 M. S. Biskind and Shelensyak10 demonstrated that animals with one ovary removed and the other transplanted to the spleen showed no estrual reactions so long as the diet was adequate to maintain the functional integrity of the liver.This observation seemed to provide an excellent means of ascertai... |
| Databáze: | OpenAIRE |
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