Chemical and microbiological investigations of metal ion interaction with norfloxacin

Autor:	A.M. Gharaibeh, M. Sheikh Salem, H. N. Alkaysi, Mohamed H. Abdel-Hay, Tarek Nawas
Rok vydání:	1992
Předmět:	Aqueous solution medicine.diagnostic_test Stereochemistry Chemistry Metal ions in aqueous solution Pharmaceutical Science Metal Spectrophotometry visual_art medicine visual_art.visual_art_medium Absorption (chemistry) Norfloxacin Stoichiometry Antibacterial agent Nuclear chemistry medicine.drug
Zdroj:	International Journal of Pharmaceutics. 87:73-77
ISSN:	0378-5173
DOI:	10.1016/0378-5173(92)90229-u
Popis:	This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al 3+ , Mg 2+ and Ca 2+ ). Two buffers of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar methods. The ratios were NFX:AL 3+ , 2:1 and 3:1 for the NFX:Mg 2+ complex. The formation of a complex with Al 3+ enhanced the water solubility of the drug. Microbiological studies indicated decreased activity of norfloxacin in the presence of metal ions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0da0fad55c5ac56bbd090a0a234fb804 https://doi.org/10.1016/0378-5173(92)90229-u Zobrazit plný text záznamu