Highly Regioselective Synthesis of 3,6-Disubstituted 2-(Methylsulfanyl)pyrimidin-4(3H)-ones

Autor:	Alessandra S. da Silveira, Josiane M. dos Santos, Laura A. Souza, Marcio M. Lobo, Marcos A. P. Martins, Helio G. Bonacorso, Nilo Zanatta
Rok vydání:	2015
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Chemistry Aryl Organic Chemistry Regioselectivity Medicinal chemistry Catalysis Alkyl
Zdroj:	Synthesis. 47:3947-3955
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0035-1560470
Popis:	This study reports a simple and highly regioselective synthesis of a new series of 3,6-disubstituted 2-(methylsulfanyl)pyrimidin-4(3H)-ones, in which the 6-substituents are methyl or aryl groups and the 3-substituents are alkyl, allyl, phenyl, benzyl, or 2-phenylethyl groups. The products are obtained in good yields by cyclocondensation of the appropriate 4-substituted 4-methoxy-1,1,1-trichloroalk-3-en-2-ones with nonsymmetric 1-substituted 2-methylisothiourea sulfates under mild basic conditions.
Databáze:	OpenAIRE
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