| Popis: |
Sir d We read the study by Venkitaraman et al. [1] in which they concluded that triple-negative breast cancers exhibit an elevated risk and an earlier occurrence of brain metastases. They suggested several reasons for a higher propensity for brain metastases in triple-negative breast cancer patients. We want to add another reason. A recent study by Bos et al. [2] looked at the genes that mediate breast cancer metastasis to the brain. They identified the cyclooxygenase COX2, the epidermal growth factor receptor (EGFR) ligand HBEGF, and the alpha2,6-sialyltransferase ST6GALNAC5 as mediators of cancer cell passage through the blood–brain barrier. Furthermore, one of the pivotal studies on basal-like breast cancer showed that EGFR expression is one of the surrogate markers for a specific definition of basal-like breast cancer [3]. Therefore, the tendency for triple-negative cancer cells to metastasise to the brain may be explained by their higher expression of EGFR. Further studies are needed to confirm this proposal. |
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