Pyridine-Fused 2-Pyridones via Povarov and A3 Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding
| Autor: | Pardeep Singh, Christian Bartens, Anders Olofsson, Kristoffer Brännström, Dan E. Adolfsson, Andrew G. Cairns, Jörgen Ådén, Fredrik Almqvist |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry Organic Chemistry Substrate (chemistry) 010402 general chemistry Amyloid fibril 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Bridged Bicyclo Compounds Pyridine Structure–activity relationship Surface modification Tricyclic |
| Zdroj: | The Journal of Organic Chemistry. 84:3887-3903 |
| ISSN: | 1520-6904 0022-3263 |
| DOI: | 10.1021/acs.joc.8b03015 |
| Popis: | We here describe the use of three-component reactions to synthesize tricyclic pyridine ring-fused 2-pyridones. The developed protocols have a wide substrate scope and allow for the installation of ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|