RIBAVIRIN: The analysis of a polymorphic substance by LC-MS and FTIR spectroscopy

Autor: R. D. Satzger, L. E. Ellis, K. R. Stewart, A. C. Machal, T. W. Brueggemeyer, R. A. Flurer
Rok vydání: 1998
Předmět:
Zdroj: AIP Conference Proceedings.
ISSN: 0094-243X
DOI: 10.1063/1.55776
Popis: The FTIR laboratory often has the task of identifying unknown pharmaceuticals. This case involves unknown capsules received at the Forensic Chemistry Center. Through extensive searching of pharmaceutical data bases, it was concluded that the capsules might contain ribavirin, which is classified as an anti-viral agent. Mass spectral analysis (LC-MS) concluded that the capsules contained ribavirin; however, the FTIR results did not agree with the mass spectral results. Additional experiments were performed and the results demonstrate the capabilities of FTIR to discern differences between polymorphic forms of a substance, such as ribavirin, when other techniques are unable to provide this information.
Databáze: OpenAIRE