Capillary dynamics, interstitial fluid and the lymphatic system
| Autor: | Mahesh Nirmalan, Andrew Haggerty |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Tissue fluid
biology Capillary action business.industry Starling Context (language use) Critical Care and Intensive Care Medicine biology.organism_classification 03 medical and health sciences 0302 clinical medicine Anesthesiology and Pain Medicine Lymphatic system Interstitial fluid Biophysics Starling equation Medicine 030212 general & internal medicine business Process (anatomy) 030217 neurology & neurosurgery |
| Zdroj: | Anaesthesia & Intensive Care Medicine. 20:182-189 |
| ISSN: | 1472-0299 |
| Popis: | The regulation of small blood vessels (arterioles, venules and capillaries) and the formation of interstitial fluid at the capillary beds is an important process in the understanding of the healthy circulation. Traditionally, the Starling forces have been at the very heart of our understanding of this system. However more recent work shows that the trans-vascular fluid flux is significantly lower than what one would expect on the basis of Starling's forces alone and hence alternative explanations have been sought to understand the process of tissue fluid formation. In this context the role of the endothelial glycocalyx layer (or EGL) has drawn substantial interest. The EGL is a dynamic, active interface between the blood and the endothelial cells. It is formed by membrane-bound glycoproteins, proteoglycans and polysaccharides, producing a hydrated gel-like layer on the luminal surface of the vascular endothelium of approximately 500–2000 nm thickness. In this paper we review some of these emerging concepts and propose alternative ideas to understand some frequent clinical conditions and their treatment. |
| Databáze: | OpenAIRE |
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