| Popis: |
Morphine in therapeutic dosage in man exhibited in the majority of instances an inhibitory effect on the fasting gastric secretion. Over 95% of the cases studied showed a reduction of volume and approximately 50% a corresponding drop in the free acidity. Only in 4 instances did a mild increase of the acidity take place after the injection of the drug. The depressive effect was found to be more marked when the patient was quiet and drowsy under the influence of morphine. The inhibitory action of morphine was, on the whole, rather weak for it was easily overcome by stimuli of chemical, psychic, or gastronomic origin. The effects of small doses of morphine in the dog were inconsistent. In one dog, morphine seemed to produce a mild stimulation, while in the other, both stimulation and inhibition were observed on different occasions. The difference in results between man and dog is probably due to the fundamental difference in their respective reactions towards the particular drug. |
