Investigation of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid

Autor: Alexander D. Tretyakov, Andrey N. Komogortsev, M. M. Krayushkin, Boris V. Lichitsky, Arkady A. Dudinov
Rok vydání: 2019
Předmět:
Zdroj: Chemistry of Heterocyclic Compounds. 55:818-822
ISSN: 1573-8353
0009-3122
DOI: 10.1007/s10593-019-02542-1
Popis: Herein, we report the studies of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid. General methods for the synthesis of 6-methyl-3,4-dihydropyrano[3,2-b]pyran-2,8-diones, 3-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)propanoic acid amides and esters, as well as 7-oxo-7H-furo[3,2-b]pyran-3-ylacetic acids were elaborated. An efficient synthesis of spiro-condensed dihydropyranones containing 5-hydroxy-2-methyl-4H-pyran-4-one fragment was developed.
Databáze: OpenAIRE
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