| Autor: |
Terri Goss Kinzy, Jens Cavallius, William C. Merrick, Wendy L. Zoll |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
The Translational Apparatus ISBN: 9781461360216 |
| DOI: |
10.1007/978-1-4615-2407-6_63 |
| Popis: |
Two recent developments have allowed for the identification of a “family” of EF-Tu-like proteins. The first is the biochemical characterization of several proteins which bind aminoacyl-tRNAs in a GTP-dependent manner. The second has been the identification of sequence identity elements that are similar to EF-Tu and many of which would allow for a similar three dimensional structure. A key element in this second part has been the emergence of a 2.6 A resolution crystal structure for Escherichia coli EF-Tu (Kjeldgaard and Nyborg, 1992). This report discusses the evolution of prokaryotic EF-Tu into its eukaryotic counterpart EF-la as well as the evolution of EF-Tu into proteins with distinct, but related functional properties. While not all of the family members have been characterized biochemically, based upon their similarity to EF-Tu and the presence of the three GTP consensus elements, it is likely that all the family members function by binding aminoacyl-tRNA in a GTP-dependent manner. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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