521 Prevalence and Impact of Restless Legs in Patients with Myasthenia Gravis
| Autor: | Mohanad AlGaeed, Henry J. Kaminski, Inmaculada Aban, Michelle Feese, Gary Cutter, Tarrant McPherson, Ikjae Lee, Elias G. Karroum |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Activities of daily living business.industry Symptom aggravating factors medicine.disease Myasthenia gravis Quality of life (healthcare) Mood Patient Self-Report Physiology (medical) mental disorders Physical therapy Medicine In patient Neurology (clinical) Restless legs syndrome business |
| Zdroj: | Sleep. 44:A205-A206 |
| ISSN: | 1550-9109 0161-8105 |
| Popis: | Introduction Restless legs syndrome (RLS) is a sensori-motor disorder characterized by an urge to move the limbs during inactivity alleviated at least partially by walking/stretching. By contrast, myasthenia gravis (MG) is a neuromuscular disease with fluctuating weakness aggravated by continued muscle activity. Only a few studies addressed the prevalence of RLS in MG patients with limitations related to small sample size and/or usage of non-validated RLS screening tools. The aim of this study was to revisit the prevalence and impact of RLS in a large sample of MG patients using the validated 13-item short-form Cambridge-Hopkins diagnostic questionnaire for RLS (CH-RLSq13). Methods The MG foundation of America patient registry was used to survey MG patients. Only patients aged ≥18 years, residing in the USA, and who answered “yes” to the question “Has your doctor diagnosed you with MG?” were included in this study. A survey including the CH-RLSq13, demographic information, disease related history, and patient reported outcomes including the MG15-item Quality of Life (MG-QOL15) and the MG-Activities of Daily Living (MG-ADL) instruments was sent to MG registry participants as part of the semi-annual follow up. Results A total of 630 MG patients (age: 62.8±13.2; 54.9% Women; 94.6% White) completed the survey and met eligibility criteria (22% of patients receiving the survey). The prevalence of RLS was 14.8% (93/630). Clinically significant RLS (moderately/extremely distressing RLS ≥2–3 days/week) was present in 53 (8.4%) MG patients. MG patients with (versus without) RLS were significantly younger (p=0.0061), more women (p=0.0440), with higher (worse) depression (p Conclusion Clinically significant RLS is prevalent in MG patients and is associated with a negative impact on mood, daily activities, and quality of life. Therefore, from a clinical practice it seems warranted to screen for RLS in MG patients. Support (if any) This study was not funded. |
| Databáze: | OpenAIRE |
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