Synthesis and Biological Activity of Triazole Derivatives of Osajin

Autor:	K.M.Ch. Appa Rao, M. Suri Appa Rao, G. Nageswara Rao, Ch. Venkata ramanaiah, L.V. Ramana
Rok vydání:	2021
Předmět:	010404 medicinal & biomolecular chemistry 010405 organic chemistry Chemistry Triazole derivatives Biological activity General Chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences
Zdroj:	Asian Journal of Chemistry. 33:1267-1272
ISSN:	0975-427X 0970-7077
Popis:	In the present study, osajin-1,2,3-triazole hybrids were designed, synthesized and evaluated for their anti-proliferative activity against MCF-7, PC-3 and Hela cell lines. Many of the synthesized hybrid derivatives were found potent than the parent compound, osajin (1). All the semi-synthesized derivatives (3a-j) were characterized by using mass and NMR spectroscopic techniques. Among the newly synthesized compounds, 3c, 3d, and 3e were shown promising activities against the tested cell lines compared with doxorubicin standard. In addition, molecular docking studies of the synthesized compounds have shown a good correlation with in silico molecular docking analysis by exhibiting strong interactions with the inhibitor HERA-protein.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0d786bebadb1c0e2a26e9f5330a5714b https://doi.org/10.14233/ajchem.2021.23195 Zobrazit plný text záznamu