Catalytic application of task specific ionic liquid on the synthesis of benzoquinazolinone derivatives by a multicomponent reaction

Autor:	Anirban Sarkar, Matiur Rahman, Monoranjan Ghosh, Alakananda Hajra, Adinath Majee
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Hydrogen bond Organic Chemistry Biginelli reaction Iminium Biochemistry Aldehyde Catalysis chemistry.chemical_compound chemistry Thiourea Drug Discovery Ionic liquid Organic chemistry Quinazolinone
Zdroj:	Tetrahedron Letters. 55:235-239
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2013.11.011
Popis:	Benzoquinazolin-2-one derivatives were synthesized by using a catalytic amount of task specific ionic liquid, [1-methyl-3-(4-sulfobutyl)imidazolium-4-methylbenzenesulfonate] through a one-pot multicomponent Biginelli reaction of α-tetralone, aldehyde, and urea/thiourea in excellent yields within a short reaction time. Mechanism studies suggest that the reaction proceeds through iminium intermediate and C2-H of the TSIL plays a major role on its catalytic activity. The catalyst has been reused four times without any significant loss in catalytic activity. Large scale reaction by using this TSIL suggests the applicability of this methodology for bulk synthesis of quinazolinone derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0d7521d881f10edb0af783414b90a981 https://doi.org/10.1016/j.tetlet.2013.11.011 Zobrazit plný text záznamu Full Text from ScienceDirect