Influence of the scan time point when assessing hypoxia in 18F-fluoromisonidazole PET: 2 vs. 4 h
| Autor: | Takuya Toyonaga, Shunsuke Terasaka, Kohsuke Kudo, Sho Furuya, Shigeru Yamaguchi, Keiichi Magota, Tohru Shiga, Nagara Tamaki, Osamu Manabe, Hiroyuki Kobayashi, Kentaro Kobayashi, Yuji Kuge, Kenji Hirata |
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| Rok vydání: | 2019 |
| Předmět: |
18F-Fluoromisonidazole
medicine.diagnostic_test Tumor hypoxia business.industry Brain tumor Standardized uptake value General Medicine Hypoxia (medical) medicine.disease 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Positron emission tomography Interquartile range 030220 oncology & carcinogenesis medicine Radiology Nuclear Medicine and imaging medicine.symptom business Nuclear medicine |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 47:1833-1842 |
| ISSN: | 1619-7089 1619-7070 |
| Popis: | 18F-fluoromisonidazole (18F-FMISO) is the most widely used positron emission tomography (PET) tracer for imaging tumor hypoxia. Previous reports suggested that the time from injection to the scan may affect the assessment of 18F-FMISO uptake. Herein, we directly compared the images at 2 h and 4 h after a single injection of 18F-FMISO. Twenty-three patients with or suspected of having a brain tumor were scanned twice at 2 and 4 h following an intravenous injection of 18F-FMISO. We estimated the mean standardized uptake value (SUV) of the gray matter and white matter and the gray-to-white matter ratio in the background brain tissue from the two scans. We also performed a semi-quantitative analysis using the SUVmax and maximum tumor-to-normal ratio (TNR) for the tumor. At 2 h, the SUVmean of gray matter was significantly higher than that of white matter (median 1.23, interquartile range (IQR) 1.10–1.32 vs. 1.04, IQR 0.95–1.16, p |
| Databáze: | OpenAIRE |
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