Serotonin Involvement in the Action of Antipsychotic Drugs

Autor:	Frans Awouters, P. A. J. Janssen, Carlos J. E. Niemegeers
Rok vydání:	1990
Předmět:	Cinanserin Risperidone Dopamine medicine.medical_treatment 5-HT2 receptor Dopamine receptor D2 medicine Ritanserin Serotonin Pharmacology Antipsychotic Psychology medicine.drug
Zdroj:	Serotonin ISBN: 9789401073530
DOI:	10.1007/978-94-009-1912-9_70
Popis:	The study of the interaction of antipsychotic drugs with central neurotransmission has implicated serotonin at least as early as dopamine. The interest in serotonin antagonism was not sustained because central dopamine D2 antagonism was found to be the common activity of all antipsychotics and clinical studies with methysergide and cinanserin were disappointing. The development of selective 5HT2 antagonists devoid of partial agonist activity revived the interest in the physiological and pathological role of serotonin. Ritanserin and risperidone have applications in psychiatry by virtue of potent, neurologically safe 5HT2 antagonism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0d676edcfba9859d9ba95b5fdd975cd7 https://doi.org/10.1007/978-94-009-1912-9_70 Zobrazit plný text záznamu