Late occurrence of progressive multifocal leukoencephalopathy after anti‐CD19 chimeric antigen receptor T‐cell therapy

Autor:	Nirmal Andrapalliyal, Brian T. Hill, Brad Pohlman, Allison L. Weathers, Agrima Mian
Rok vydání:	2021
Předmět:	business.industry Progressive multifocal leukoencephalopathy Central nervous system Encephalopathy Neurotoxicity Hematology General Medicine medicine.disease Chimeric antigen receptor Lymphoma 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology medicine Chimeric Antigen Receptor T-Cell Therapy Stem cell business 030215 immunology
Zdroj:	European Journal of Haematology. 106:584-588
ISSN:	1600-0609 0902-4441
DOI:	10.1111/ejh.13583
Popis:	Progressive multifocal leukoencephalopathy (PML) is a life-threatening infection of the central nervous system in immunocompromised patients, with an established predilection in Non-Hodgkin's lymphoma and stem cell transplant recipients. In the era of chimeric antigen receptor T-cell therapy (CAR T-cell), the occurrence of new-onset neurological symptoms and encephalopathy in this patient population can be attributed to a variety of factors, including therapy related neurotoxicity or disease progression. PML has not been implicated as a common cause of encephalopathy in CAR T-cell therapy recipients, and the identification of such rare infections is important to guide prognosis and treatment decisions. We hereby report the first case of late occurrence of PML, over one year after CAR T-cell therapy, for a patient with relapsed large B-cell lymphoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0d60240c2ed97ffa93ab90a14e7b378b https://doi.org/10.1111/ejh.13583 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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