| Autor: |
Edoardo Trevisiol, T. Angusti, Francesca Dazzara, M. Iudicello, Valerio Podio, Andrea Skanjeti, G. M. Delgado Yabar |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Journal of Neuroimaging. 24:257-265 |
| ISSN: |
1051-2284 |
| DOI: |
10.1111/jon.12008 |
| Popis: |
BACKGROUND AND PURPOSE Over the last two decades 123I-FP-CIT-SPECT, has been used to discriminate neurodegenerative Parkinsonian syndrome from other diseases. BasGan is a freely available software that assists 123I-FP-CIT-SPECT evaluation by estimating semiquantitative values for each basal nucleus and compares the results to a database of healthy subjects. The aims of this study were: (1) to assess the accuracy of qualitative analysis and of semiquantitative, BasGan-assisted evaluations of 123I-FP-CIT-SPECT; (2) to compare the accuracy of both methods when applied to “doubtful” cases; (3) to appreciate the reproducibility of the BasGan-assisted evaluations. MATERIALS AND METHODS Seventy-eight patients were included in this 4-year follow-up study. The diagnostic cut-off for semiquantitative uptake values of each basal nucleus was determined based on ROC curves analysis. Accuracy scores were calculated for the entire population and for “doubtful” cases. Intra- and interoperator reproducibility was assessed. RESULTS Accuracy of the software-assisted analyses was high for data from each nucleus. In “doubtful” exams accuracy was higher when using BasGan as opposed to relying solely on visual assessment. Intra- and interoperator reproducibility of the BasGan-assisted evaluations was good to excellent. CONCLUSION BasGan-assisted evaluations of 123I-FP-CIT-SPECT were very useful, particularly in “doubtful” cases. Multicenter studies are mandatory before routine use of BasGan. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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