Ocular surface analysis in patients diagnosed with X-linked ichthyosis
| Autor: | Manuel Caro-Magdaleno, B. Mataix-Albert, Jesús Montero-Iruzubieta, P. Molina-Solana, Enrique Rodríguez-de-la-Rúa, F.B. Domínguez-Serrano |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
genetic structures Meibomian gland law.invention 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Stroma Confocal microscopy law Ophthalmology medicine In patient X-linked ichthyosis medicine.diagnostic_test business.industry Ichthyosis General Medicine medicine.disease eye diseases medicine.anatomical_structure 030221 ophthalmology & optometry sense organs business Ocular surface |
| Zdroj: | Archivos de la Sociedad Española de Oftalmología (English Edition). 95:565-568 |
| ISSN: | 2173-5794 |
| DOI: | 10.1016/j.oftale.2020.04.018 |
| Popis: | Seven patients (14 eyes) diagnosed with X-linked ichthyosis were studied using the Schirmer test, biomicroscopy, tonometry, endothelial count, optical coherence tomography, Pentacam®, ocular surface analyser, and confocal microscopy. The mean age was 33.83±20.17 years (range: 7-64 years). The most frequent findings in biomicroscopy were Meibomian glands dysfunction (83.3%) and stromal corneal opacities (33%). The tear break-up time was found shortened in 25% of the eyes. Confocal microscopy (both eyes) revealed activated keratocytes with hyper-reflective particles inside them in the anterior stroma and outside them in the posterior stroma. It is believed that the inclusion of the use of confocal microscopy will help in a better understanding of the corneal pathology associated with ichthyosis X, as well as new characteristics of these patients. |
| Databáze: | OpenAIRE |
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