Systemic oxidative stress in victims of Bothrops snakebites
| Autor: | Juliana de Ornellas Strapazzon, Juliana Bastos, Thais Regina Garlet, Manuel Rosa de Oliveira Lino, Tânia Silvia Fröde, Danilo Wilhelm Filho, Eduardo Benedetti Parisotto, Ivan Ricardo Zimermann, Marlene Zanin, Ana Maria Moratelli, Rodrigo Fagundez |
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| Rok vydání: | 2015 |
| Předmět: |
Bothrops jararaca
Health Toxicology and Mutagenesis Glutathione reductase Biomedical Engineering Pharmacology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Lipid peroxidation chemistry.chemical_compound Artificial Intelligence medicine TBARS General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification General Immunology and Microbiology biology Chemistry General Neuroscience Glutathione peroxidase General Medicine Glutathione biology.organism_classification Immunology Bothrops General Agricultural and Biological Sciences Oxidative stress |
| Zdroj: | Journal of Applied Biomedicine. 13:161-167 |
| ISSN: | 1214-0287 1214-021X |
| Popis: | The genus Bothrops is responsible for approximately 90% of snakebites in Brazil. In the present study biomarkers of oxidative stress (OS) were evaluated in the blood of victims of snakebites from Bothrops jararaca and Bothrops jararacussu. Patient monitoring started from the emergency entrance at the hospital up to 30 days, groups divided as follows: time 0 (t0), 24 hours (t24h), 7 days (t7d) and 30 days (t30d). The activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and myeloperoxidase (MPO), as well as the contents of reduced glutathione (GSH), vitamin E, lipid peroxidation (TBARS), protein carbonyls (PC) were examined in blood. Initial determinations revealed increased CAT, GR and GPx activities and decreased SOD and GST activities together with the depletion of GSH contents, while markers of oxidative damage showed increased TBARS levels and decreased PC concentrations in victims of snakebite compared to controls (blood donors). Regarding the temporal effect, no statistical differences among the groups were detected for the distinct parameters analyzed. The responses obtained in OS biomarkers in victims of snakebite compared to healthy subjects indicate that Bothrops envenomation promoted a pronounced and persistent systemic OS in the blood of those subjects. |
| Databáze: | OpenAIRE |
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