Pharmacokinetic modeling of polychlorinated dibenzo-p-dioxins (PCDDs) and furans (PCDFs) in cows
| Autor: | A.P.J.M. de Jong, A.K.D. Liem, H. Everts, H.J.G.M. Derks, P.L.M. Berende, M. Olling |
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| Rok vydání: | 1994 |
| Předmět: |
Environmental Engineering
Chemistry Health Toxicology and Mutagenesis Pharmacokinetic modeling Public Health Environmental and Occupational Health Adipose tissue Model parameters General Medicine General Chemistry Pollution Bioavailability Pharmacokinetics Polychlorinated Dibenzo-p-dioxins Environmental chemistry Environmental Chemistry Toxicokinetics |
| Zdroj: | Chemosphere. 28:711-715 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/0045-6535(94)90222-4 |
| Popis: | A physiologically based pharmacokinetic (PB-PK) model for 2,3,7,8-TCDD in cows is described. Uptake in tissues appears to be blood flow limited except in adipose. Sensitive model parameters are fat tissue volume and bioavailability. The agreement between predicted and experimental data is fairly good. |
| Databáze: | OpenAIRE |
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