ChemInform Abstract: Directing Bromination of Piperazine-2,5-diones

Autor:	Jason B. Harper, Christopher J. Easton, Christina L. L. Chai, T. W. Badran, D. M. Page
Rok vydání:	2010
Předmět:	Piperazine chemistry.chemical_compound chemistry Stereochemistry Intramolecular force Intermolecular force Substituent Surface modification Halogenation General Medicine Medicinal chemistry
Zdroj:	ChemInform. 26
ISSN:	0931-7597
DOI:	10.1002/chin.199544171
Popis:	From intermolecular and intramolecular competition experiments, it has been established that, by comparison with an N-methyl substituent, an N-acetyl group deactivates glycine residues in piperazine-2,5-diones towards free-radical bromination. Combined with the ease of introduction and removal of N-acetyl substituents, the deactivating effect provides a method for regiocontrolled functionalization of these compounds.
Databáze:	OpenAIRE
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