Prognostic Models Turn the Heat(IT)up on FLT3ITD-Mutated AML
| Autor: | Paolo Gallipoli, Brian J. P. Huntly |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
Poor prognosis Myeloid business.industry Myeloid leukemia medicine.disease 3. Good health body regions 03 medical and health sciences Leukemia 0302 clinical medicine medicine.anatomical_structure Oncology hemic and lymphatic diseases 030220 oncology & carcinogenesis medicine Tandem Repeat Sequence Cancer research In patient 030212 general & internal medicine Receptor Tyrosine Kinase Gene business psychological phenomena and processes Prognostic models |
| Zdroj: | Clinical Cancer Research. 25:460-462 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-18-3146 |
| Popis: | The presence of internal tandem duplications (ITD) in the FLT3 receptor tyrosine kinase gene have long been known to confer a poor prognosis in patients with acute myeloid leukemia. Now, specific structural features of the ITDs are also suggested to alter patient outcome, including sensitivity to targeted therapies, prompting their evaluation in therapeutic algorithms. See related article by Schwartz et al., p. 573 |
| Databáze: | OpenAIRE |
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