Effect of prolonged aflatoxin B1 administration on blood serum oestradiol-17β and progesterone concentrations of goats during the anoestrus period
| Autor: | E. Theodosiadou, A. G. Lymberopoulos, G. D. Kourousekos, S. Belibasaki, Constantin Boscos |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Aflatoxin medicine.medical_specialty Period (gene) 0402 animal and dairy science Radioimmunoassay 04 agricultural and veterinary sciences Biology 040201 dairy & animal science 03 medical and health sciences 030104 developmental biology Blood serum Endocrinology Blood chemistry Internal medicine Toxicity medicine Animal Science and Zoology Oestradiol 17β Aflatoxin B |
| Zdroj: | Czech Journal of Animal Science. 60:164-170 |
| ISSN: | 1805-9309 1212-1819 |
| Popis: | The effect of prolonged aflatoxin B 1 (AFB 1 ) administration on blood serum oestradiol-17β and progesterone concentrations in goats during the anoestrus period was investigated. Thirty Greek indigenous goats were used; 10 goats received, per os , 50 μg (treated group T50) and 10 goats received 100 &μg (treated group T100) AFB 1 /day/head, respectively, for 31 days, while 10 goats served as controls (C). Blood samples were collected from each goat twice a week to determine serum oestradiol-17β and progesterone concentrations by radioimmunoassay. Multiple linear regression analysis revealed a significant (P < 0.05) positive dependence of blood serum oestradiol-17β concentration over group (C = 0, T50 = 50, T100 = 100), in a dose-dependent manner, and a significant (P < 0.05) negative dependence over time (0-31 days, from the onset to the end of AFB 1 administration). Linear regression analysis revealed a significant (P < 0.05) positive dependence of blood serum progesterone concentration over group (C = 0, T50 = 50, T100 = 100), in a dose-dependent manner. Pearson's correlation coefficient revealed a significant (P < 0.05) positive correlation between blood serum oestradiol-17β and progesterone concentration, but only in the goats of the control group. In conclusion, the prolonged administration of 100 or even of 50 μg AFB 1 /day/head during the anoestrus period, increased blood serum oestradiol-17β and progesterone concentrations of goats, in a dose-dependent manner, and in the treated groups disturbed the positive correlation between oestradiol-17β and progesterone concentration shown in the goats of the control group. |
| Databáze: | OpenAIRE |
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