Interstitial pneumonitis and pulmonary vasculitis in a patient taking an L-tryptophan preparation

Autor:	Y Bogaerts, D Van Renterghem, J Vanvuchelen, M Praet, P Michielssen, V Blaton, JP Willemot
Rok vydání:	1991
Předmět:	Pulmonary and Respiratory Medicine
Zdroj:	European Respiratory Journal. 4:1033-1036
ISSN:	1399-3003 0903-1936
Popis:	A case is presented of interstitial pneumonitis and pulmonary vasculitis ascribed to the ingestion of an L-tryptophan preparation. An unintended rechallenge supported the causal relationship. There was neither myalgia nor peripheral eosinophilia. Bronchoalveolar lavage fluid contained 12% eosinophils but few were present in the surgical lung biopsy specimen. Lung infiltrates receded after withdrawal of the drug and treatment with steroids. Dyspnoea and pulmonary hypertension persisted. Cyclophosphamide had no effect. Sclerodermiform skin lesions appeared as a late sequel. Chromatographic analysis of the L-tryptophan revealed no suspect impurities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0d204a6b9f68f717a35b0ae729cefd07 https://doi.org/10.1183/09031936.93.04081033 Zobrazit plný text záznamu