Gas chromatographic determination of the configuration of isovaline in antiamoebin, samarosporin (emerimicin IV), stilbellin, suzukacillins and trichotoxins

Autor:	H. Brückner, K. Kruse, Wilfried A. König, Guenther Jung, G. J. Nicholson
Rok vydání:	1980
Předmět:	chemistry.chemical_classification Chromatography Stereochemistry Organic Chemistry Clinical Biochemistry Peptide Chiral stationary phase Biochemistry Analytical Chemistry Emerimicin chemistry.chemical_compound Isovaline chemistry Antiamoebin Samarosporin Gas chromatography Trichotoxin
Zdroj:	Chromatographia. 13:209-214
ISSN:	1612-1112 0009-5893
Popis:	The D-(resp. R) configuration of isovaline (=2-ethylalanine) was proved for the peptide antibiotics antiamoebin, Tu 165 (CBS 382.62), stilbellin, samarosporin (=emerimicin IV), suzukacillin B (A), trichotoxin A-40 and A-50. This contradicts the previously reported L-configuration for isovaline in antiamoebin and emerimicin IV. The configuration was determined by GC of the N-trifluoroacetyl-isovaline n-propyl ester on glass capillary columns coated with the chiral stationary phase N-propionyl-L-valine tert.-butylamide polysiloxane (Chirasil Val). The D-configuration of the isovaline from trichotoxin A-40 was also established independently using GC of N-pentafluoro-propionyl-isovaline (+)-3-methyl-2-butyl esters on glass capillary columns coated with OV 17.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0d195a4d1fef9893bad51a88cace4c70 https://doi.org/10.1007/bf02261873 Zobrazit plný text záznamu Full text from SpringerLink