The effect of the eutectic composition on the outcome of kinetically and thermodynamically controlled resolutions that are based on the formation of diastereomers

Autor:	Péter Bagi, Elemér Fogassy, Emese Pálovics, Zsolt Szeleczky
Rok vydání:	2015
Předmět:	Chemical substance Resolution (mass spectrometry) Chemistry Organic Chemistry Diastereomer Mandelic acid Free amino Catalysis Inorganic Chemistry chemistry.chemical_compound Organic chemistry Physical and Theoretical Chemistry Enantiomer Eutectic system
Zdroj:	Tetrahedron: Asymmetry. 26:377-384
ISSN:	0957-4166
Popis:	The resolution of mandelic acid and its derivatives with free amino acids has been investigated. It was observed that the corresponding diastereomers were formed under either kinetic or thermodynamic control, which considerably influenced the purity of the enantiomeric mixtures obtained. It was found that in these particular resolutions, the eutectic composition of either the racemic compound or the resolving agent influenced the purity of the enantiomeric mixtures of the mandelic acid derivatives obtained after resolution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0d0790486981748080c5222d25be2dfb https://doi.org/10.1016/j.tetasy.2015.02.006 Zobrazit plný text záznamu Full Text from ScienceDirect