ChemInform Abstract: Synthesis and Evaluation of a Series of Aryl(e)fused Pyrazolo(4,3-c) pyridines with Potential Anxiolytic Activity

Autor:	Ian Thomson Forbes, Loudon Julia Mary, Jane M. Nicholass, Christopher N. Johnson, Mervyn Thompson, Neil Upton, G. E. Jones
Rok vydání:	2010
Předmět:	Chemistry medicine.drug_class Stereochemistry GABAA receptor medicine.medical_treatment Aryl General Medicine Combinatorial chemistry Anxiolytic chemistry.chemical_compound Anticonvulsant Sedative medicine Diazepam Anxiolytic agents medicine.drug
Zdroj:	ChemInform. 22
ISSN:	0931-7597
Popis:	A series of pyrazolo[4,3-c]pyridines has been synthesized and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different from that of diazepam. A number of the compounds possess higher affinity for central benzodiazepine receptors than diazepam, yet show less anticonvulsant activity and are less sedative. The structure-activity relationships of these potential anxiolytic agents are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0cfd429f1f1d15010e557dd6f90fdbac https://doi.org/10.1002/chin.199108211 Zobrazit plný text záznamu Plný text