| Autor: | Hudye Sa, L. Donegan, James A. Hardin, D. G. Gall, Merle E. Olson |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Lagomorpha biology Physiology Chemistry Gastroenterology Glucose transporter Absorption (skin) biology.organism_classification Jejunum medicine.anatomical_structure Nutrient Endocrinology Pulmonary surfactant Basal (medicine) Internal medicine medicine Nonionic surfactant Food science |
| Zdroj: | Digestive Diseases and Sciences. 44:1423-1427 |
| ISSN: | 0163-2116 |
| DOI: | 10.1023/a:1026660004203 |
| Popis: | Nonionic surfactants are commonly present inmany prepared foods and drug formulations as stabilizingagents. The aim of the current study was to examine theeffect of the common nonionic surfactant Tween-80 on jejunal glucose transport. New Zealand Whiterabbits (800-1200 g) were fasted for 24 hr. Jejunaltissue was stripped and mounted in short-circuitedUssing chambers. Unidirectional 3-O-methyl glucose fluxes were determined during a 15-min basaltransport period and a subsequent 15-min experimentalperiod after the mucosal addition of Tween-80 at finalconcentrations of 0.001%, 0.01%, 0.05%, and 0.1%.Tween-80 at final concentrations of 0.1% and 0.05%significantly increased net 3-O-methyl glucose transportover basal levels. The increase in Jnet wasdue to a significant increase in the absorptive Jm-s flux. Tween-80 at 0.01% and0.001% did not significantly alter net glucose transportalthough Jm-s was significantly increased inthe presence of 0.01% Tween-80. Tween-80, inconcentrations commonly found in prepared foods, enhances theintestinal absorption of glucose. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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