Bilateral simultaneous orbital hemorrhage and compartment syndrome as the presenting sign of acquired hemophilia A in an 11-year-old girl
| Autor: | Arif O. Khan, Raed Shatnawi, Samar Awni Shweiki |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Prolonged Partial Thromboplastin Time business.industry media_common.quotation_subject Mixing study Head trauma Surgery 03 medical and health sciences Ophthalmology 0302 clinical medicine hemic and lymphatic diseases Pediatrics Perinatology and Child Health 030221 ophthalmology & optometry medicine Girl Fresh frozen plasma Acquired Factor VIII Deficiency Compartment (pharmacokinetics) business Retrobulbar Hemorrhage media_common |
| Zdroj: | Journal of American Association for Pediatric Ophthalmology and Strabismus. 24:124-126 |
| ISSN: | 1091-8531 |
| DOI: | 10.1016/j.jaapos.2020.01.002 |
| Popis: | A previously healthy 11-year-old girl presented with bilateral orbital compartment syndrome secondary to retrobulbar hemorrhages requiring emergency cantholysis. Four days earlier she had sustained head trauma without symptoms until her acute presentation. A basic hematologic profile was remarkable for a prolonged partial thromboplastin time, which did not completely correct with a 1:1 mixing study. This result raised suspicion for the most common acquired deficiency of clot stability, acquired factor VIII deficiency (acquired hemophilia A). Low factor VIII levels and the presence of autoantibodies against autologous factor VIII were confirmed. The child was treated daily with fresh frozen plasma and showed marked improvement over the ensuing days and weeks. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect