The ΔT thermal dose concept 2: in vitro cellular effects

Autor:	Morton W. Miller, Marsh J. Edwards, Jacques S. Abramowicz, William C. Dewey, Linda F Battaglia, Salvatore Mazza
Rok vydání:	2004
Předmět:	Hyperthermia Physiology Cell Cavia Biology biology.organism_classification medicine.disease Biochemistry In vitro Guinea pig medicine.anatomical_structure Cell culture medicine Biophysics Doubling time General Agricultural and Biological Sciences Thermal dose Developmental Biology
Zdroj:	Journal of Thermal Biology. 29:151-156
ISSN:	0306-4565
DOI:	10.1016/j.jtherbio.2004.01.002
Popis:	The results of this project provide proof of concept for an analysis of hyperthermia-induced in vitro cellular effects in relation to a thermal dose determination with a temperature-differential basis from each cell line's historical physiological temperature (HPT). Human ( Homo sapiens ) fetal cells, whose HPT was assumed to be 37°C, and guinea pig ( Cavia porcellus ) fetal cells, whose HPT was assumed to be 39.5°C, were used. It was hypothesized that in vitro cellular functionality (e.g. , fastest cell doubling time) would be maximal at each line's respective HPT and decrease with temperatures above and below each line's HPT. The hypothesis was supported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ce86393485282af3d3fb11a6bc0c295 https://doi.org/10.1016/j.jtherbio.2004.01.002 Zobrazit plný text záznamu Full Text from ScienceDirect