Synthesis of α- and β-Galactopyranose-Configured Isomers of Cyclophellitol and Cyclophellitol Aziridine

Autor:	Benjamin Murray, Herman S. Overkleeft, Johannes M. F. G. Aerts, Hans van den Elst, Jeroen D. C. Codée, Berend Gagestein, Thomas J. M. Beenakker, Gijsbert A. van der Marel, Lianne I. Willems, Wouter W. Kallemeijn, Erwin R. van Rijssel
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Cyclophellitol 010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Physical and Theoretical Chemistry Aziridine 010402 general chemistry 01 natural sciences 0104 chemical sciences 3. Good health
Zdroj:	European Journal of Organic Chemistry. 2014:6044-6056
ISSN:	1434-193X
DOI:	10.1002/ejoc.201402589
Popis:	Cyclophellitol and cyclophellitol aziridine are potent and irreversible mechanism-based inhibitors of retaining β-glucosidases. Alterations in the configuration of these compounds can lead to irreversible inhibition of different classes of retaining glycosidases. We have recently reported on the design of a set of α-galactopyranose-configured cyclophellitol and cyclophellitol aziridine derivatives that inhibit human retaining α-galactosidases. Moreover, we have shown
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ce5e6dde17a21ffd332316d8265b0b1 https://doi.org/10.1002/ejoc.201402589 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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