Análise comparativa da hiperplasia intimal após o implante de stents com e sem sirolimus em artérias coronárias de pequeno calibre
| Autor: | Luis Fernando Tanajura, Andrea Abizaid, Amanda G. M. R. Sousa, Fausto Feres, Áurea J. Chaves, Fernando Devito, J. Eduardo Sousa, Rodolfo Staico, Mattos La, Alexandre Abizaid |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Intimal hyperplasia business.industry medicine.medical_treatment Stent equipment and supplies medicine.disease Surgery Coronary artery disease surgical procedures operative Restenosis Angioplasty medicine In patient cardiovascular diseases Cardiology and Cardiovascular Medicine Nuclear medicine business Survival rate Angiographic restenosis |
| Zdroj: | Arquivos Brasileiros de Cardiologia. 86:268-275 |
| ISSN: | 0066-782X |
| DOI: | 10.1590/s0066-782x2006000400006 |
| Popis: | OBJECTIVE: This study aimed at evaluating reduction in intimal hyperplasia volume following angioplasty using sirolimus-eluting stents (Cypher™) compared with thin-strut bare-metal stents (Pixel™) in patients with small vessels. METHODS: Eighty patients with coronary artery disease were prospectively included in two consecutive series, the first using sirolimus-eluting stents (50) and the second using bare-metal stents (30). RESULTS: The use of sirolimus-eluting stents reduced: in-stent net volume obstruction [5.0% (SE = 0.77) x 39.0% (SE = 4.72), p < 0.001], in-stent late loss [0.25 mm (SE = 0.03) x 1,11 mm (SE = 0.13), p < 0,001], in-segment late loss [0.30 mm (SE = 0.04) x 0.83 mm (SE = 0.11), p < 0.001], in-stent restenosis (0% x 33.3%, p < 0.001) and in-segment restenosis (4% x 36.7%, p < 0.001). The event-free survival rate was 96% in the sirolimus-eluting stent group versus 86.7% in the bare-metal stent group (BMS) (p = 0.190). CONCLUSION: Sirolimus-eluting stents are superior to thin-strut bare-metal stents in reducing intimal hyperplasia (less in-stent obstruction and less late lumen loss) in patients with small vessels. The use of these stents significantly reduced angiographic restenosis at eight months. |
| Databáze: | OpenAIRE |
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