The synthesis of peptide fragments of high affinity receptor FcɛRI and their binding to allergen-specific immunoglobulins E

Autor:	O. V. Gribovskaya, V. P. Martinovich, V. P. Golubovich, L. R. Vykhristenko, D. K. Novikov, V. V. Yanchenko
Rok vydání:	2012
Předmět:	Specific immunoglobulins chemistry.chemical_classification biology Chemistry Organic Chemistry Peptide medicine.disease_cause Immunoglobulin E Biochemistry Molecular biology chemistry.chemical_compound Allergen medicine Peptide synthesis biology.protein Bioorganic chemistry Antibody Receptor
Zdroj:	Russian Journal of Bioorganic Chemistry. 38:253-260
ISSN:	1608-330X 1068-1620
Popis:	Using computer analysis, a minimal sequence of Arg136-Asn137-Trp138-Asp139 that can bind to IgE C3 and C4 fragments was determined for the high-affinity receptor FcɛRI, a key protein of IgE-dependent allergic reactions of the immediate type. A number of peptides containing the Arg-Asn-Trp-Asp sequence were proposed as model analogues of the FcɛRI receptor. It was shown that these peptides manifested immunobiological effects and bound to IgE. The peptides were demonstrated to bind to IgE serum antibodies specific to the Dermatophagoides pteronyssinus allergen isolated from plasma of patients with allergic bronchial asthma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0cc9d52272fc2684bfea0a316cb38d0c https://doi.org/10.1134/s1068162012030041 Zobrazit plný text záznamu Full text from SpringerLink