Antibacterial Activity of 1,2-Alkanediol against Staphylococcus aureus and Staphylococcus epidermidis
| Autor: | Maki Miura, Minako Okukawa, Yoshimune Nonomura, Takamasa Watanabe, Hiroyuki Konno, Shigekazu Yano |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Minimum bactericidal concentration biology 030309 nutrition & dietetics Chemistry General Chemical Engineering 04 agricultural and veterinary sciences General Medicine General Chemistry Antimicrobial medicine.disease_cause biology.organism_classification 040401 food science Microbiology 03 medical and health sciences Minimum inhibitory concentration 0404 agricultural biotechnology Staphylococcus aureus Staphylococcus epidermidis medicine Antibacterial activity Staphylococcus Bacteria |
| Zdroj: | Journal of Oleo Science. 68:759-763 |
| ISSN: | 1347-3352 1345-8957 |
| DOI: | 10.5650/jos.ess19074 |
| Popis: | 1,2-Alkanediol exhibits antibacterial activity against several bacteria and yeast. However, few studies have reported antimicrobial tests on skin microbiome. Bacterial microbiome on the skin surface include Staphylococcus aureus (S. aureus), which causes rough skin and inflammation in atopic dermatitis and Staphylococcus epidermidis (S. epidermidis), which enhances innate immunity. In this study, the minimal inhibitory concentration (MIC) was evaluated for 1,2-alkanediol comprising 4-12 carbon atoms against S. aureus and S. epidermidis. 1,2-Alkanediol comprising 6-12 carbon atoms exhibited antimicrobial activity against both species of Staphylococcus. The antibacterial activity depended on the alkyl chain length. In addition, the minimum bactericidal concentration (MBC) on agar was evaluated for 1,2-alkanediol comprising 6-12 carbon atoms. 1,2-Octanediol and 1,2-decanediol exhibited significant bactericidal activity. |
| Databáze: | OpenAIRE |
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