Cyclic flow alterations and neointimal proliferation following experimental coronary stenosis and endothelial injury
| Autor: | Claude R. Benedict, Paolo Golino, Sheng-Kun Yao, L. Maximilian Buja, Janice McNatt, James T. Willerson, Sidney Murphree, H. Vernon Anderson |
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| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Pathology Intimal hyperplasia biology business.industry medicine.drug_class Fissipedia Blood flow biology.organism_classification Receptor antagonist medicine.disease Pathophysiology medicine.anatomical_structure Restenosis Internal medicine medicine Cardiology Platelet business Artery |
| Zdroj: | Developments in Cardiovascular Medicine ISBN: 9789401048194 |
| DOI: | 10.1007/978-94-011-1854-5_24 |
| Popis: | We evaluated the hypothesis that recurrent platelet aggregation as evidenced by the frequency and severity of cyclic coronary blood flow variations is an important pathophysiologic factor in the development of neointimal proliferation. In 24 chronically instrumented dogs, variable degrees of coronary artery neointimal proliferation were observed 3 weeks after mechanical injury of the arterial endothelium and the placement of an external coronary artery constrictor. The severity of neointimal proliferation at 21 days was closely related to the frequency and severity of cyclic coronary blood flow variations during the initial 7 days after instrumentation of the animals. Pharmacological therapy with a dual thromboxane A2 synthetase inhibitor and receptor antagonist and a serotonin S2 receptor antagonist frequently was successful in abolishing cyclic blood flow variations and appeared to attenuate neointimal proliferation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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