Natural progression and clinical significance of incidentally detected pulmonary nodules in radiotherapy planning CT scans of breast cancer patients: a retrospective cohort
| Autor: | Paul Gopu Gopurathingal, Sasidharan Balu Krishna, Selvamani Backianathan, Venkata Krishna Reddy Pilaka, Sunitha Susan Varghese |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Lung business.industry medicine.medical_treatment Cancer Retrospective cohort study Disease medicine.disease Radiation therapy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Breast cancer Oncology 030220 oncology & carcinogenesis medicine Radiology Nuclear Medicine and imaging Clinical significance 030212 general & internal medicine Radiology business Indeterminate |
| Zdroj: | Journal of Radiotherapy in Practice. 15:359-363 |
| ISSN: | 1467-1131 1460-3969 |
| DOI: | 10.1017/s1460396916000376 |
| Popis: | AimIndeterminate pulmonary nodules incidentally detected during radiological imaging completed for radiotherapy planning always creates dilemma for the oncologist. The purpose of this study is to evaluate the clinical significance of pulmonary nodules incidentally detected in patients undergoing locoregional radiotherapy for breast cancer and present a retrospective analysis of the natural progression of such nodules.MethodsA retrospective review of computed tomography scans of breast cancer patients who underwent radiotherapy over a period of 3 years to screen out patients with indeterminate lung nodules was undertaken. This was correlated with the patient and tumour characteristics and the status of the disease at last follow-up.ResultsOf the 132 patients reviewed 28 had indeterminate lung nodules. Of the 28 patients, four had progressive lung nodules on follow-up. Subgroup analyses did not show any significant correlation.Discussion and conclusionOne fifth of patients may present with incidentally detected lung nodules. Multiple nodules, ER negative status and locally advanced breast cancer may point to a higher risk of these nodules progressing to metastatic cancer. There is no indication to stop locoregional therapy in the presence of indeterminate nodules, but close follow-up of high-risk group is recommended. |
| Databáze: | OpenAIRE |
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