Interaction between the antibacterial compound, oleuropein, and model membranes
| Autor: | C. Mestres, Mathias Kurt Herrlein, M. Asunción Alsina, Jorge Casas-Sanchez |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Phosphatidylglycerol
Phosphatidylethanolamine Chromatography Polymers and Plastics biology biology.organism_classification medicine.disease_cause Enterobacteriaceae chemistry.chemical_compound Colloid and Surface Chemistry Membrane chemistry Oleuropein Materials Chemistry medicine Physical and Theoretical Chemistry Escherichia coli Bacteria Antibacterial agent |
| Zdroj: | Colloid and Polymer Science. 285:1351-1360 |
| ISSN: | 1435-1536 0303-402X |
| DOI: | 10.1007/s00396-007-1693-x |
| Popis: | Oleuropein, a secoiridoid glycoside extracted from the olive tree, Olea europaea L., has been described as showing antibacterial properties. However, the exact mechanism of these antimicrobial properties is not yet well understood. In the present study, we have studied the interaction of oleuropein with phosphatidylglycerol (PG) as a model membrane for Staphylococcus aureus (S. aureus) (Gram-positive bacteria) and phosphatidylethanolamine and Escherichia coli (E. coli) lipid extract as a model membrane for E. coli (Gram-negative bacteria). The study has been carried out using monolayers as model membranes and using kinetics at constant area and compression isotherms with Brewster angle microscopy (BAM) observations. The results show that oleuropein interacts in higher extent with PG monolayers, which is related with its stronger antibacterial effect against Gram-positive bacteria. The effects on the membrane are probably produced at the cell surface because oleuropein did not form stable mixed monolayers with the lipids assayed at the air/water interface. |
| Databáze: | OpenAIRE |
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