Perioperative opioid requirements are decreased in hypoxic children living at altitude
| Autor: | Cornelius B. Groenewald, Jukka Räsänen, Niki M. Dietz, Carmen Morales, Jennifer A. Rabbitts |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
business.industry Narcotic medicine.medical_treatment Perioperative Effects of high altitude on humans Hypoxia (medical) medicine.disease Fentanyl Obstructive sleep apnea Anesthesiology and Pain Medicine Opioid Anesthesiology Anesthesia Pediatrics Perinatology and Child Health medicine medicine.symptom business medicine.drug |
| Zdroj: | Pediatric Anesthesia. 20:1078-1083 |
| ISSN: | 1155-5645 |
| Popis: | Summary Objectives: To investigate the effect of altitude on perioperative opioid requirements in otherwise healthy children. Aim: To investigate whether children living and having surgery at high altitude received different doses of fentanyl than those living and having surgery at sea level. Background: Recent studies in animals (Anesthesiology, 105, 2006 and 715) and children with obstructive sleep apnea (Anesthesiology, 105, 2006 and 665; Anesthesiology 100, 2004 and 806) suggest that analgesic effects of exogenous opioids are enhanced by hypoxia. However, the effects of hypoxia on perioperative narcotic requirements in otherwise healthy children have not been previously reported. Methods/materials: We reviewed retrospectively the opioid requirements of pediatric patients who underwent cleft lip or palate surgery during Smile Network International mission trips to Cusco and Lima, Peru between 2007 and 2009. Patients who had surgery at high altitude were compared to those who had surgery at sea level. All patients received a standardized anesthetic with intravenous fentanyl as the only perioperative opioid. Results: Hundred and two patients had surgery at 3399 m above sea level (masl) (Cusco) and 169 patients had surgery at 150 masl (Lima). Patients at high altitude had significantly lower baseline oxygen saturations (92 ± 4% vs 98 ± 3%; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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