UPLC-MS/MS analysis of SZJ-1207 in mouse plasma and brain and application in pharmacokinetic studies

Autor:	Dake Qi, Yingying Sun, Bingying Hu, Hai An, Haiyang Lin, Jinjun Fang, Yang Wei
Rok vydání:	2023
Předmět:	General Chemistry
Zdroj:	Acta Chromatographica.
ISSN:	2083-5736 1233-2356
DOI:	10.1556/1326.2022.01102
Popis:	SZJ-1207 is an antidepressant natural product with a steroidal structure extracted from Stephanotis mucronata. It is a novel antidepressant candidate molecule and all its pharmacokinetic properties have not been reported. In this pharmacokinetic study in mice following oral administration, an accurate and sensitive UPLC-MS/MS method was established and evaluated to measure SZJ-1207 concentrations in mouse plasma and brain samples. The results provide information regarding the pharmacokinetics of SZJ-1207 as a potential antidepressant.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ca831a44eabdf7996467bee7143c2df https://doi.org/10.1556/1326.2022.01102 Zobrazit plný text záznamu