Synthesis and characterization of mesoporous silica SBA 15 improved the efficacy of CORM-2 against hypoxia reoxygenation injury

Autor:	Gino A. Kurian, Sri Rahavi Boovarahan, Meenakshi Ramanathan, Sakthivel Gandhi
Rok vydání:	2021
Předmět:	Aqueous solution Ligand Mechanical Engineering Nanoparticle Mesoporous silica Catalysis chemistry.chemical_compound chemistry Mechanics of Materials General Materials Science Amine gas treating Fourier transform infrared spectroscopy Carbon monoxide Nuclear chemistry
Zdroj:	Journal of Porous Materials. 28:1969-1977
ISSN:	1573-4854 1380-2224
Popis:	Carbon monoxide releasing molecule-2 (CORM-2) exhibited protection against cardiac hypoxia reoxygenation injury (H/R). However, its poor water solubility and short half-life restrict its clinical usage. The present study aims to investigate whether encapsulation of CORM-2 in mesoporous silica (MSN-A-CORM-2) can enhance its anti-H/R effect in cardiac cell lines H9C2 (cardiomyoblast) and 3T3 (fibroblast). Mesoporous silica nanoparticles (MSN) were synthesized by co-operative self-assembly technique through solvothermal strategy and terminated with amine functional groups (MSN-A). The ligand, CORM-2, was linked to the terminal amine group in mesoporous silica. The physicochemical characterization of the compound was made by using SEM, TEM, FTIR, and EDS analysis. Further, we evaluated the biological effect of MSN-A-CORM-2 against H/R in H9C2 and 3T3 cells. The results demonstrated that MSN-A-CORM-2 was less toxic as compared to that of standard CORM-2. The comparable potential of CORM-2 in combating H/R got enhanced upon encapsulation with mesoporous silica.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ca06e9cccb98497cc17a9fc52095438 https://doi.org/10.1007/s10934-021-01132-x Zobrazit plný text záznamu Full text from SpringerLink