Chlamydia pneumoniae and COPD exacerbation
| Autor: | Sebastian L. Johnston, Peter A. Lambert, Peter MacCallum, T A R Seemungal, Jadwiga A. Wedzicha |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pulmonary and Respiratory Medicine
COPD Chlamydia biology Exacerbation business.industry medicine.disease_cause Fibrinogen medicine.disease Peripheral blood mononuclear cell Immunoglobulin G respiratory tract diseases Pneumonia Chlamydophila pneumoniae Immunology medicine biology.protein business medicine.drug |
| Zdroj: | Thorax. 57:1087 |
| ISSN: | 0040-6376 |
| DOI: | 10.1136/thorax.57.12.1087-a |
| Popis: | We read with interest the recent paper by Blasi et al which showed that Chlamydia pneumoniae infection is associated with higher rates of exacerbation and airway microbial colonisation in patients with COPD.1 We have prospectively studied patients in the East London COPD study with daily monitoring using diary cards to detect COPD exacerbation defined using the same criteria.2,3 Serum microimmunofluorescence (MIF) immunoglobulin G (IgG) titres for C pneumoniae were measured in 110 patients (FEV1% 41.7 (18.4)) with stable COPD during 1 year with simultaneous estimation of plasma fibrinogen and serum interleukin 6 (IL-6); 26% of the patients had IgG titres of ≥1 in 16 (fig 1). High C pneumoniae IgG titres were not related to FEV1 % predicted, exacerbation frequency, plasma fibrinogen, or serum IL-6 levels. In their paper Blasi et al did not report whether there was a relation between MIF titres and exacerbation frequency. Blasi and colleagues found that 43% of patients when stable were positive for C pneumoniae by DNA polymerase chain reaction (PCR) using peripheral blood mononuclear cells (PBMCs). At exacerbation they have only shown data for the 34 (of 61) who consented to the antibiotic trial and all 34 were positive for C pneumoniae . In our study a further 33 patients (FEV1% 39.8 (16.3)) were simultaneously sampled using nasopharyngeal aspirates and induced sputum when stable and during 43 COPD exacerbations. We found no C pneumoniae using a nested reverse transcriptase PCR adapted from Cunningham et al 4 … |
| Databáze: | OpenAIRE |
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