NAP Family Histone Chaperones: Characterization and Role in Ontogenesis
| Autor: | A. A. Akishina, Yu. E. Vorontsova, E. E. Kuvaeva, O. B. Simonova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0303 health sciences biology Nucleosome assembly Chemistry 01 natural sciences Chromatin remodeling Chromatin Cell biology Nap 03 medical and health sciences Histone Transcription (biology) biology.protein Nucleosome 030304 developmental biology 010606 plant biology & botany Developmental Biology Histone binding |
| Zdroj: | Russian Journal of Developmental Biology. 51:343-355 |
| ISSN: | 1608-3326 1062-3604 |
| Popis: | Histone chaperones are a class of proteins that bind and transport histones, preventing their chaotic aggregation when forming nucleosomes. Histone chaperones of the NAP (Nucleosome Assembly Protein) family contain a highly conserved central NAP domain, which is necessary for histone binding and nucleosome assembly. They are an essential component in creating and maintaining the eukaryotic chromatin dynamics on which the transcription of many genes depends. The review considers the NAP family of proteins and its specific representatives: NAP1, NAP2, and CG5017/Hanabi. Since they are canonical histone transporters providing effective chromatin remodeling, NAP family proteins are involved in neuronal differentiation, spermatogenesis, and long-term memory formation, which indicates the importance of this family in ontogenesis. |
| Databáze: | OpenAIRE |
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