Preparation of 11C-nitromethane and an example of its use as a radiolabeling precursor

Autor:	Bengt Långström, Sharon Stone-Elander, Karl-Olof Schoeps, Christer Halidin, Torgny Greitz
Rok vydání:	1988
Předmět:	chemistry.chemical_classification Nitromethane Organic Chemistry Iodide Inorganic chemistry Chemical reactor Biochemistry Analytical Chemistry chemistry.chemical_compound chemistry Drug Discovery Radiology Nuclear Medicine and imaging Sodium nitrite Spectroscopy
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 25:749-758
ISSN:	0362-4803
DOI:	10.1002/jlcr.2580250708
Popis:	No-carrier-added 11C-nitromethane has been prepared from 11C-methyl iodide in a one-pot reaction by use of silver or sodium nitrite in different solvents. A conversion of up to 87% was obtained within 3 min. It could easily be distilled from high-boiling solvents to another reaction vessel (140°C, 3 min). Its potential as a radiolabeling precursor in condensations with aldehydes was shown in the synthesis of 11C-β-nitrostyrene (85% conversion after 3–5 min).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0c828cceeb103ffcdee5200d35443cc8 https://doi.org/10.1002/jlcr.2580250708 Zobrazit plný text záznamu Plný text