Cytotoxic flavonoids from the stem bark ofLonchocarpusaff.fluvialis
| Autor: | Norman R. Farnsworth, Cecília T. T. Blatt, Daniel Chávez, Heebyung Chai, John M. Pezzuto, Geoffrey A. Cordell, James G. Graham, A. Douglas Kinghorn, Fernando Cabieses |
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| Rok vydání: | 2002 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Chalcone Traditional medicine biology Dibenzoylmethane Chemistry Stereochemistry Flavonoid Pterocarpan Biological activity Pharmacognosy biology.organism_classification Lonchocarpus chemistry.chemical_compound visual_art visual_art.visual_art_medium Bark |
| Zdroj: | Phytotherapy Research. 16:320-325 |
| ISSN: | 0951-418X |
| DOI: | 10.1002/ptr.889 |
| Popis: | Activity-guided fractionation of a chloroform-soluble extract of Lonchocarpus aff. fluvialis stem bark using a human epidermoid (KB) tumour cell line as a monitor afforded five rotenoids, one pterocarpan, one chalcone, three flavanones, one flavone and one triterpenoid. All of the compounds isolated proved to be of previously known structure. Among them, the rotenoids (-)-sumatrol and (+/-)-villosinol, the dibenzoylmethane derivative (+)-3,4-methylenedioxy-2'-methoxy-[2",3":4',3']-furanodibenzoylmethane, and the flavanones (-)-isoglabrachromene and (-)-candidone have been shown to exhibit significant cytotoxic activity against human cancer cells for the first time. This is the first report of the chemical constituents of this species, and the profile of compounds obtained was in accordance with the established chemosystematic patterns of species in the tribe Tephrosieae (Leguminosae, Papilionoideae). |
| Databáze: | OpenAIRE |
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